Piper Longum Extract
Piper Nigrum Extract/Long Piper Extract
Active Ingredient : Piperine 5%, Piperine 95%, Rutin 4% & Rutin 6%
Common Name : Indian Long Pepper
Chemical Constituents & Components : Main chemical components are piperine, rutin, beta- caryophyllene piperyline, piperoleines, piperamine, sabinene, chavicin, pinene, phellandrene, pentadecane, beta-bisabolene, linalool & limonene.
Action :
Rutin:
1. It enhances the metabolic rate of body thus act as thermogenesis.
2. It increases the plasma concentration of coenzyme Q10.
3. It is a strong inhibitor of UDP-glucose dehydrogenase (UDP-GDH)
4. It exerts stronger effects on intestinal glucuronidation.
5. It stimulates the digestive enzymes of pancreas, enhances the digestive capacity and significantly reduces the gastrointestinal food transit time.
6. It protects against oxidative damage by inhibiting or quenching free radicals and reactive oxygen species.
Piperine :
1. It is an N-methyl-d-aspartate (NMDA) receptor antagonistic, which contributes to its anti-convulsant property.
2. It causes decrease in total lipid contents by inhibiting enzymes involved in fat synthesis.
3. It is inhibitor of hepatic and intestinal glucuronidation.
4. It lowers the serum levels of both the thyroid hormones, thyroxin (T (4)), triiodothyronine (T (3)) and glucose concentrations with a concomitant decrease in hepatic 5'D enzyme & glucose-6-phospatase (G-6-Pase) activity.
5. It increases gastric acid secretion.
Curing Diseases : 1. It is used to treat flatulence, gout, laryngitis, and paralysis.
2. It is used to treat abdominal tumors and gastric ulcers.
3. It is improve the digestive system.
4. It enhances the immune system.
Research Information : Piper longum extract possesses significant immunomodulatory and anti-tumor activity. It increases total white blood cell count and enhances bone marrow. It also shows antitumor activity and shows cytotoxicity. (Ref. Sunila, E.S., and Kuttan, G., Immunomodulatory and antitumor activity of Piper longum Linn. and piperine, J Ethnopharmacology. 2004 Feb; 90 (2-3): 339-346)
Possible Combinations : Piper longum zingiber officinalis piper nigrum (treatment of asthma)
